Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones.
نویسندگان
چکیده
An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 38 شماره
صفحات -
تاریخ انتشار 2014